Intestinal Sinonasal Adenocarcinoma with Distinct Immunophenotype
نویسندگان
چکیده
منابع مشابه
Sinonasal Adenocarcinoma: Update on Classification, Immunophenotype and Molecular Features.
Adenocarcinomas of the sinonasal tract may originate from respiratory surface epithelium or the underlying seromucinous glands. These malignancies are divided into salivary-type adenocarcinomas and non-salivary-type adenocarcinomas. The latter are further divided into intestinal-type and nonintestinal-type adenocarcinomas. This review provides an update on tumor classification, differential dia...
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BACKGROUND Patients with intestinal-type sinonasal adenocarcinoma (ITAC) have an unfavorable prognosis and new therapeutic approaches are needed to improve clinical management. METHODS Genetic analysis of 96 ITACs was performed by microarray comparative genomic hybridization and immunohistochemistry and correlated to previously obtained mutation, methylation, and protein expression data, and ...
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Intestinal-type adenocarcinoma is the second most frequent sinonasal adenocarcinoma. High incidence of these tumors is seen among workers with occupational wood dust exposure, particularly of hardwood dusts. Intestinal-type adenocarcinoma has striking histomorphologic and immunophenotypic similarities with colorectal adenocarcinomas, but on the level of molecular pathologic mechanisms these tum...
متن کاملBenign Lesions in Mucosa Adjacent to Intestinal-Type Sinonasal Adenocarcinoma
Occupational exposure to wood dust is a strong risk factor for the development of intestinal-type sinonasal adenocarcinoma (ITAC); however, knowledge on possible precursor lesions or biomarkers is limited. Fifty-one samples of tumor-adjacent mucosa and 19 control samples of mucosa from the unaffected fossa of ITAC patients were evaluated for histological changes and p53 protein expression. Mild...
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We present a patient with a biopsy-proved sinonasal intestinal-type adenocarcinoma who presented with moderate confusion. He was found to have bifrontal hemorrhages, which to our knowledge has not been previously described in the literature for this entity. Intestinal-type adenocarcinoma should be in the differential diagnosis of aggressive lesions in the base of the skull with intracranial spr...
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ژورنال
عنوان ژورنال: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
سال: 2017
ISSN: 2249-782X
DOI: 10.7860/jcdr/2017/31819.11014